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KMID : 0606320080240010015
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Journal of Phamacetical Sciences Sookmyung Women s University
2008 Volume.24 No. 1 p.15 ~ p.21
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Antimelanogenic Effect of Sulforaphane in Murine Melanoma B16F10 Cells
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Song Kyung-Hee
Kim Sung-Eun
Yu Ji-Sun
Kim An-Keun
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Abstract
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Sulforaphane is an isothiocyanate found in cruciferous vegetables. It has been studied as an anti-oncology and antibiotic agent. There are some other studies which have shown sulforaphane relating to the skin. In order to explore the anti-melanogenesis effect, reactive oxygen species (ROS) level, melanin contents, and tyrosinase activity was measured in B16F10 mouse melanoma cells. The viability of sulforaphane-treated B16F10 was measured by MTT, and the treating concentration was decided more than IC_(80). ROS level was a little lowered than control. Tyrosinase activity was also lowered than control in all concentration, but melanin contents was reduced in one concentration. In conclusion, sulforaphane revealed a little anti-oxidant effect and it showed the possibility of sulforaphane as an anti-melanogenesis agent in B16F10.
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KEYWORD
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sulforaphane, tyrosinase, anti-melanogenesis
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